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In pancreatic cells, GLP-1R activation signals primarily through G proteinmediated signaling pathways involving cyclic adenosine monophosphate (cAMP), protein kinase A ( PKA ), and cAMP response elementbinding protein ( CREB ), thereby enhancing glucose-dependent insulin secretion and supporting -cell function

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GLP-1 receptor agonists (GLP-1 RAs) are long-acting versions of this signal (liraglutide, semaglutide, dulaglutide, and the dual GIP/GLP-1 agent tirzepatide) developed to treat type 2 diabetes and, more recently, obesity